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Placenta may have mechanism that protects fetus from COVID; vaccines safe with rheumatic diseases

The following is a abstract of some current research on COVID-19. They embrace analysis that warrants additional examine to corroborate the findings and that has but to be licensed by peer evaluation.

Placenta may shed proteins to maintain virus out

The placenta may have a option to shield itself and the fetus from an infection with the coronavirus, a small examine suggests.

Researchers studied 24 girls who gave beginning between July 2020 and April 2021. Eight had symptomatic COVID-19 within the second trimester, eight have been sick from the virus within the third trimester, and eight weren’t contaminated throughout being pregnant. When COVID-19 occurred in being pregnant, significantly in the course of the third trimester, placenta cells appeared to “shed” a floor protein known as ACE2 that the virus makes use of to interrupt into cells and infect them, leaving fewer gateways for entry. Women who had COVID-19 within the third trimester had excessive ranges of an enzyme known as ADAM17 that is understood to assist ACE2 launch itself from the cell floor, the researchers reported in The American Journal of Pathology.

The placenta may be sensing the maternal COVID-19 an infection “and possibly putting in place this mechanism to help shed off ACE2, prevent SARS-CoV-2 from invading the placenta and passing on to the fetus,” mentioned Elizabeth Taglauer of Boston Medical Center. Earlier research have proven that placental cells turn into contaminated in solely about 7per cent to 20per cent of pregnancies the place the mom has COVID-19, Taglauer mentioned. When the virus does by some means get into the placenta, it not often reaches the fetus, she added. Her crew plans additional research of “protection pathways” that may be holding the virus out of placental cells and away from fetal blood vessels.

COVID vaccines safe in rheumatic, musculoskeletal diseases

COVID-19 vaccines seem like safe for folks with rheumatic and musculoskeletal diseases and are prone to set off flares – a sudden worsening of signs – in lower than 5per cent of circumstances, researchers have discovered.

The findings have been based mostly on knowledge from 5,121 sufferers in 30 international locations. Severe flares occurred in fewer than 1per cent of sufferers after vaccination, they discovered. Overall, flares have been extra prone to happen in sufferers with energetic illness, based on a report printed in Annals of the Rheumatic Diseases. “However, it is important to note that flares can occur as part of the … disease, and the observed percentages of flare would be compatible with the natural history of the disease rather than necessarily caused by vaccines against SARS-CoV-2,” mentioned Dr. Pedro Machado of University College London. The common examine participant was 72 years previous, and most have been girls. Many had inflammatory joint diseases, connective tissue diseases or vasculitis and have been receiving varied mixtures of disease-modifying antirheumatic medication, immunosuppressants, and different drugs.

Most had acquired the Pfizer/BioNTech vaccine (70per cent), adopted by pictures from AstraZeneca (17per cent) and Moderna (8per cent). “Our findings should provide reassurance to rheumatologists, other health professionals and vaccine recipients, and promote confidence in the safety of COVID-19 vaccination in people with inflammatory rheumatic diseases,” Dr. Machado mentioned.

Peer-review doesn’t result in main adjustments in “preprints”

Two research printed on Tuesday in PLoS Biology counsel that papers posted on so-called preprint servers earlier than present process formal peer evaluation don’t change considerably earlier than publication in medical journals.

One examine in contrast greater than 180 experiences posted in the course of the first 4 months of the pandemic on the preprint servers medRxiv and bioRxiv to the variations ultimately printed in peer-reviewed journals. Roughly 83per cent of COVID-related papers and 93per cent of non-COVID-related papers didn’t change from their preprint to ultimate printed variations, they discovered. When the researchers did determine adjustments, within the majority of circumstances these adjustments didn’t qualitatively change the conclusions of the paper, they mentioned.

The different examine used machine studying to investigate the relationships between almost 18,000 preprints on the bioRxiv server and their printed variations. Most manuscripts had solely modest adjustments in wording in the course of the peer-review and publication course of, the researchers discovered.

Click for a Reuters graphic on vaccines in improvement.

(Reporting by Nancy Lapid; Additional reporting by Marilynn Larkin; Editing by Bill Berkrot)



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